PyDev 4.5.1 brings niceties such as an improvement on the code-completion so that properties declared with @property no longer show arguments parenthesis and Ctrl+1 can be used inside a bracketed statement to wrap/unwrap its contents over multiple lines (thanks to yohell). Also, the refactoring, parsing and search had some fixes, but the major changes were in the debugger.
The debugger is much faster and has optional Cython modules for even additional speedups.
In short, the debugger is overall 40% faster without Cython and 138% faster with Cython in the benchmarks created -- although in real world cases I expect even better gains as the benchmarks were done for the cases where the debugger has more overhead than usual.
Graphs with more details on the improvements may be seen at:
https://www.speedtin.com/reports/7_pydevd_cython (performance results with cython).
https://www.speedtin.com/reports/8_pydevd_pure_python (performance results without cython).
Also, the debugger backend is now also available through "pip install pydevd" (https://pypi.python.org/pypi/pydevd), so, it's easier to setup the remote debugging in a different machine (note that users shouldn't need to install the debugger, only if doing a remote debugging session).
As a note, I'd like to thank JetBrains, which helped on sponsoring the performance improvements in the PyDev Debugger (as it's also the debugger backend used by PyCharm).
For LiClipse users, 2.5.1 (just released too) includes the latest PyDev.